4z9g

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==Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry==
==Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry==
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<StructureSection load='4z9g' size='340' side='right' caption='[[4z9g]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
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<StructureSection load='4z9g' size='340' side='right'caption='[[4z9g]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z9g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z9G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z9g]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacteria_phage_RB51 Enterobacteria phage RB51] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z9G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Q5:3,6-DIMETHYL-N-(PENTAN-3-YL)-2-(2,4,6-TRIMETHYLPHENOXY)PYRIDIN-4-AMINE'>1Q5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1Q5:3,6-DIMETHYL-N-(PENTAN-3-YL)-2-(2,4,6-TRIMETHYLPHENOXY)PYRIDIN-4-AMINE'>1Q5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k5y|4k5y]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9g OCA], [https://pdbe.org/4z9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z9g RCSB], [https://www.ebi.ac.uk/pdbsum/4z9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z9g ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRHR1, CRFR, CRFR1, CRHR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9g OCA], [http://pdbe.org/4z9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z9g RCSB], [http://www.ebi.ac.uk/pdbsum/4z9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z9g ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN]] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref>
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[https://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref> [https://www.uniprot.org/uniprot/C3V2B5_BPR51 C3V2B5_BPR51] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[HAMAP-Rule:MF_04110]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Enterobacteria phage RB51]]
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[[Category: Lysozyme]]
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[[Category: Homo sapiens]]
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[[Category: Bortolato, A]]
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[[Category: Large Structures]]
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[[Category: Cheng, R K.Y]]
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[[Category: Bortolato A]]
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[[Category: Dore, A S]]
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[[Category: Cheng RKY]]
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[[Category: Hollenstein, K]]
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[[Category: Dore AS]]
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[[Category: Marshall, F H]]
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[[Category: Hollenstein K]]
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[[Category: Read, R J]]
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[[Category: Marshall FH]]
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[[Category: Family b]]
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[[Category: Read RJ]]
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[[Category: G-protein]]
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[[Category: Gpcr]]
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[[Category: Hexagonal]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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[[Category: Tnc]]
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Revision as of 07:45, 10 May 2023

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry

PDB ID 4z9g

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OCA

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