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| | <StructureSection load='4zbp' size='340' side='right'caption='[[4zbp]], [[Resolution|resolution]] 2.60Å' scene=''> | | <StructureSection load='4zbp' size='340' side='right'caption='[[4zbp]], [[Resolution|resolution]] 2.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4zbp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZBP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4zbp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZBP FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADV:ALPHA-BETA+METHYLENE+ADP-RIBOSE'>ADV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADV:ALPHA-BETA+METHYLENE+ADP-RIBOSE'>ADV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zb3|4zb3]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zbp OCA], [https://pdbe.org/4zbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zbp RCSB], [https://www.ebi.ac.uk/pdbsum/4zbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zbp ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT7, GFG1, NUDX7, At4g12720, T20K18.70 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zbp OCA], [http://pdbe.org/4zbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zbp RCSB], [http://www.ebi.ac.uk/pdbsum/4zbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zbp ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/NUDT7_ARATH NUDT7_ARATH]] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use both NADH and ADP-ribose as substrates, but not 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Exerts negative control of EDS1 signaling.<ref>PMID:15878881</ref> <ref>PMID:16154395</ref> <ref>PMID:16328543</ref> <ref>PMID:16531493</ref> <ref>PMID:17660350</ref> | + | [https://www.uniprot.org/uniprot/NUDT7_ARATH NUDT7_ARATH] Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use both NADH and ADP-ribose as substrates, but not 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Exerts negative control of EDS1 signaling.<ref>PMID:15878881</ref> <ref>PMID:16154395</ref> <ref>PMID:16328543</ref> <ref>PMID:16531493</ref> <ref>PMID:17660350</ref> |
| | + | |
| | + | ==See Also== |
| | + | *[[Nudix hydrolase 3D structures|Nudix hydrolase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Arath]] | + | [[Category: Arabidopsis thaliana]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Ding, J]] | + | [[Category: Ding J]] |
| - | [[Category: Liu, C]] | + | [[Category: Liu C]] |
| - | [[Category: Tang, Q]] | + | [[Category: Tang Q]] |
| - | [[Category: Zhong, C]] | + | [[Category: Zhong C]] |
| - | [[Category: Ampcpr]]
| + | |
| - | [[Category: Closed conformation]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Nudix]]
| + | |
| Structural highlights
Function
NUDT7_ARATH Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use both NADH and ADP-ribose as substrates, but not 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Exerts negative control of EDS1 signaling.[1] [2] [3] [4] [5]
See Also
References
- ↑ Ogawa T, Ueda Y, Yoshimura K, Shigeoka S. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. J Biol Chem. 2005 Jul 1;280(26):25277-83. Epub 2005 May 5. PMID:15878881 doi:http://dx.doi.org/M503536200
- ↑ Olejnik K, Kraszewska E. Cloning and characterization of an Arabidopsis thaliana Nudix hydrolase homologous to the mammalian GFG protein. Biochim Biophys Acta. 2005 Sep 25;1752(2):133-41. PMID:16154395 doi:http://dx.doi.org/10.1016/j.bbapap.2005.07.021
- ↑ Jambunathan N, Mahalingam R. Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling. Planta. 2006 Jun;224(1):1-11. Epub 2005 Dec 3. PMID:16328543 doi:http://dx.doi.org/10.1007/s00425-005-0183-y
- ↑ Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze JL, Bautor J, Parker JE. Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell. 2006 Apr;18(4):1038-51. Epub 2006 Mar 10. PMID:16531493 doi:http://dx.doi.org/tpc.105.039982
- ↑ Ge X, Li GJ, Wang SB, Zhu H, Zhu T, Wang X, Xia Y. AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis. Plant Physiol. 2007 Sep;145(1):204-15. Epub 2007 Jul 27. PMID:17660350 doi:http://dx.doi.org/pp.107.103374
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