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1w3o
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(New page: 200px<br /> <applet load="1w3o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w3o, resolution 1.60Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 16:11, 29 October 2007
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CRYSTAL STRUCTURE OF NIMA FROM D. RADIODURANS
Overview
5-Nitroimidazole-based antibiotics are compounds extensively used for, treating infections in humans and animals caused by several important, pathogens. They are administered as prodrugs, and their activation depends, upon an anaerobic 1-electron reduction of the nitro group by a reduction, pathway in the cells. Bacterial resistance toward these drugs is thought, to be caused by decreased drug uptake and/or an altered reduction, efficiency. One class of resistant strains, identified in Bacteroides, has, been shown to carry Nim genes (NimA, -B, -C, -D, and -E), which encode for, reductases that convert the nitro group on the antibiotic into a, non-bactericidal amine. In this paper, we have described the crystal, structure of NimA from Deinococcus radiodurans (drNimA) at 1.6 A, resolution. ... [(full description)]
About this Structure
1W3O is a [Single protein] structure of sequence from [Deinococcus radiodurans] with ACT and PYR as [ligands]. Full crystallographic information is available from [OCA].
Reference
Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans., Leiros HK, Kozielski-Stuhrmann S, Kapp U, Terradot L, Leonard GA, McSweeney SM, J Biol Chem. 2004 Dec 31;279(53):55840-9. Epub 2004 Oct 18. PMID:15492014
Page seeded by OCA on Mon Oct 29 18:16:13 2007
