7xqk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus.== |
| - | + | <StructureSection load='7xqk' size='340' side='right'caption='[[7xqk]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xqk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Schistosoma_japonicum Schistosoma japonicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XQK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xqk OCA], [https://pdbe.org/7xqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xqk RCSB], [https://www.ebi.ac.uk/pdbsum/7xqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xqk ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Cheng | + | [https://www.uniprot.org/uniprot/GST26_SCHJA GST26_SCHJA] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.[https://www.uniprot.org/uniprot/CDK3_HUMAN CDK3_HUMAN] Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.<ref>PMID:15084261</ref> <ref>PMID:18794154</ref> <ref>PMID:8846921</ref> |
| - | [[Category: Gao | + | == References == |
| - | [[Category: Huang | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schistosoma japonicum]] | ||
| + | [[Category: Cheng W]] | ||
| + | [[Category: Gao J]] | ||
| + | [[Category: Gui W]] | ||
| + | [[Category: Huang Y]] | ||
| + | [[Category: Wang F]] | ||
Revision as of 06:56, 18 May 2023
The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus.
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Categories: Homo sapiens | Large Structures | Schistosoma japonicum | Cheng W | Gao J | Gui W | Huang Y | Wang F
