1kt9
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1kt9.jpg|left|200px]] | [[Image:1kt9.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1kt9", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | | | + | --> |
| - | | | + | {{STRUCTURE_1kt9| PDB=1kt9 | SCENE= }} |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Crystal Structure of C. elegans Ap4A Hydrolase''' | '''Crystal Structure of C. elegans Ap4A Hydrolase''' | ||
| Line 23: | Line 20: | ||
==Reference== | ==Reference== | ||
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937063 11937063] | The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937063 11937063] | ||
| - | [[Category: Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)]] | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 33: | Line 29: | ||
[[Category: Rafferty, J B.]] | [[Category: Rafferty, J B.]] | ||
[[Category: Sedelnikova, S E.]] | [[Category: Sedelnikova, S E.]] | ||
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | [[Category: | + | [[Category: Nudix]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:08:46 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:08, 2 May 2008
Crystal Structure of C. elegans Ap4A Hydrolase
Overview
The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate, but not triphosphate, compounds through precise orientation of key elements of the substrate.
About this Structure
1KT9 is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:11937063 Page seeded by OCA on Fri May 2 23:08:46 2008
