1ktb

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[[Image:1ktb.gif|left|200px]]
[[Image:1ktb.gif|left|200px]]
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{{Structure
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|PDB= 1ktb |SIZE=350|CAPTION= <scene name='initialview01'>1ktb</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1ktb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase Alpha-N-acetylgalactosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.49 3.2.1.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= alpha-NAGA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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|DOMAIN=
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{{STRUCTURE_1ktb| PDB=1ktb | SCENE= }}
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|RELATEDENTRY=[[1ktc|1KTC]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktb OCA], [http://www.ebi.ac.uk/pdbsum/1ktb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ktb RCSB]</span>
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}}
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'''The Structure of alpha-N-Acetylgalactosaminidase'''
'''The Structure of alpha-N-Acetylgalactosaminidase'''
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[[Category: Hannick, L.]]
[[Category: Hannick, L.]]
[[Category: Zhu, A.]]
[[Category: Zhu, A.]]
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[[Category: (beta/alpha)8 barrel]]
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[[Category: Glycoprotein]]
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[[Category: glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:08:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:53:18 2008''
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Revision as of 20:08, 2 May 2008

Image:1ktb.gif

Template:STRUCTURE 1ktb

The Structure of alpha-N-Acetylgalactosaminidase


Overview

In the lysosome, glycosidases degrade glycolipids, glycoproteins, and oligosaccharides. Mutations in glycosidases cause disorders characterized by the deposition of undegraded carbohydrates. Schindler and Fabry diseases are caused by the incomplete degradation of carbohydrates with terminal alpha-N-acetylgalactosamine and alpha-galactose, respectively. Here we present the X-ray structure of alpha-N-acetylgalactosaminidase (alpha-NAGAL), the glycosidase that removes alpha-N-acetylgalactosamine, and the structure with bound ligand. The active site residues of alpha-NAGAL are conserved in the closely related enzyme a-galactosidase A (alpha-GAL). The structure demonstrates the catalytic mechanisms of both enzymes and reveals the structural basis of mutations causing Schindler and Fabry diseases. As alpha-NAGAL and alpha-GAL produce type O "universal donor" blood from type A and type B blood, the alpha-NAGAL structure will aid in the engineering of improved enzymes for blood conversion.

About this Structure

1KTB is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases., Garman SC, Hannick L, Zhu A, Garboczi DN, Structure. 2002 Mar;10(3):425-34. PMID:12005440 Page seeded by OCA on Fri May 2 23:08:52 2008

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