8hp8
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Engineered Endolysin EC340 derived from Gram-Negative Bacteria targeted Bacteriophage== | |
| + | <StructureSection load='8hp8' size='340' side='right'caption='[[8hp8]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8hp8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_PBEC131 Escherichia phage PBEC131]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HP8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hp8 OCA], [https://pdbe.org/8hp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hp8 RCSB], [https://www.ebi.ac.uk/pdbsum/8hp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hp8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Endolysins produced by bacteriophages play essential roles in the release of phage progeny by degrading the peptidoglycan layers of the bacterial cell wall. Bacteriophage-encoded endolysins have emerged as a new class of antibacterial agents to combat surging antibiotic resistance. The crystal structure of mtEC340M, an engineered endolysin EC340 from the PBEC131 phage that infects Escherichia coli, was determined. The crystal structure of mtEC340M at 2.4 A resolution consists of eight alpha-helices and two loops. The three active residues of mtEC340M were predicted by structural comparison with peptidoglycan-degrading lysozyme. | ||
| - | + | Crystal structure of the engineered endolysin mtEC340M.,Wang JM, Seok SH, Yoon WS, Kim JH, Seo MD Acta Crystallogr F Struct Biol Commun. 2023 May 1;79(Pt 5):105-110. doi: , 10.1107/S2053230X23002583. Epub 2023 May 3. PMID:37132476<ref>PMID:37132476</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8hp8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia phage PBEC131]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Seo MD]] | ||
| + | [[Category: Wang JM]] | ||
| + | [[Category: Yoon WS]] | ||
Revision as of 07:01, 18 May 2023
Crystal Structure of Engineered Endolysin EC340 derived from Gram-Negative Bacteria targeted Bacteriophage
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