8sl0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a bacterial gasdermin slinky-like oligomer== | |
| - | + | <StructureSection load='8sl0' size='340' side='right'caption='[[8sl0]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8sl0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vitiosangium_sp._GDMCC_1.1324 Vitiosangium sp. GDMCC 1.1324]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SL0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sl0 OCA], [https://pdbe.org/8sl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sl0 RCSB], [https://www.ebi.ac.uk/pdbsum/8sl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sl0 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/GSDM_VITXG GSDM_VITXG] Precursor of a pore-forming protein involved in defense against bacteriophages (By similarity). Expression of bGSDM and the neighboring protease gene (Ga0334635_1659) is toxic in E.coli (PubMed:35025633). Cleavage of this precursor by its dedicated protease releases the active moiety (gasdermin bGSDM, N-terminus) which inserts into membranes, forming pores and triggering cell death (By similarity).[UniProtKB:A0A0S2DNG5][UniProtKB:P0DV48]<ref>PMID:35025633</ref> Pore-forming protein that causes membrane permeabilization via a pyroptosis-like activity. Makes ring-like pores when released.[UniProtKB:P0DV48] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vitiosangium sp. GDMCC 1 1324]] | ||
| + | [[Category: Johnson AG]] | ||
| + | [[Category: Kranzusch PJ]] | ||
| + | [[Category: Mayer ML]] | ||
Revision as of 07:05, 18 May 2023
Structure of a bacterial gasdermin slinky-like oligomer
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