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5gic

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<StructureSection load='5gic' size='340' side='right'caption='[[5gic]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='5gic' size='340' side='right'caption='[[5gic]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gic]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GIC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DLC:(3R,5S)-5-{(2R,3R)-3-[(1R,2S,3Z)-3-{(2E)-2-[(3S,5R)-3,5-DIHYDROXY-2-METHYLIDENECYCLOHEXYLIDENE]ETHYLIDENE}-1,2-DIMETHYLCYCLOHEXYL]-2-METHYLBUTYL}-3-HYDROXY-3-METHYL-1-(2-PHENYLETHYL)PYRROLIDIN-2-ONE'>DLC</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLC:(3R,5S)-5-{(2R,3R)-3-[(1R,2S,3Z)-3-{(2E)-2-[(3S,5R)-3,5-DIHYDROXY-2-METHYLIDENECYCLOHEXYLIDENE]ETHYLIDENE}-1,2-DIMETHYLCYCLOHEXYL]-2-METHYLBUTYL}-3-HYDROXY-3-METHYL-1-(2-PHENYLETHYL)PYRROLIDIN-2-ONE'>DLC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gid|5gid]], [[5gie|5gie]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gic OCA], [https://pdbe.org/5gic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gic RCSB], [https://www.ebi.ac.uk/pdbsum/5gic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gic ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vdr, Nr1i1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gic OCA], [http://pdbe.org/5gic PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gic RCSB], [http://www.ebi.ac.uk/pdbsum/5gic PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gic ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Vitamin D receptor|Vitamin D receptor]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Asano, L]]
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[[Category: Rattus norvegicus]]
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[[Category: Shimizu, T]]
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[[Category: Asano L]]
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[[Category: Nuclear receptor]]
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[[Category: Shimizu T]]
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[[Category: Transcription]]
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Revision as of 07:05, 18 May 2023

Crystal structure of VDR in complex with DLAM-2P

PDB ID 5gic

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