1ktm

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[[Image:1ktm.gif|left|200px]]
[[Image:1ktm.gif|left|200px]]
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{{Structure
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|PDB= 1ktm |SIZE=350|CAPTION= <scene name='initialview01'>1ktm</scene>
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The line below this paragraph, containing "STRUCTURE_1ktm", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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{{STRUCTURE_1ktm| PDB=1ktm | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktm OCA], [http://www.ebi.ac.uk/pdbsum/1ktm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ktm RCSB]</span>
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'''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE'''
'''SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE'''
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[[Category: Liu, G.]]
[[Category: Liu, G.]]
[[Category: Zheng, J.]]
[[Category: Zheng, J.]]
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[[Category: fak]]
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[[Category: Fak]]
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[[Category: fat]]
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[[Category: Fat]]
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[[Category: focal adhension targeting domain]]
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[[Category: Focal adhension targeting domain]]
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[[Category: focal adhesion kinase]]
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[[Category: Focal adhesion kinase]]
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[[Category: helix bundle]]
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[[Category: Helix bundle]]
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[[Category: nmr]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:09:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:53:24 2008''
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Revision as of 20:09, 2 May 2008

Image:1ktm.gif

Template:STRUCTURE 1ktm

SOLUTION STRUCTURE OF FAT DOMAIN OF FOCAL ADHESION KINASE


Overview

Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeting (FAT) domain interacts with other focal adhesion molecules in integrin-mediated signaling. Localization of activated FAK to focal adhesions is indispensable for its function. Here we describe a solution structure of the FAT domain bound to a peptide derived from paxillin, a FAK-binding partner. The FAT domain is composed of four helices that form a "right-turn" elongated bundle; the globular fold is mainly maintained by hydrophobic interactions. The bound peptide further stabilizes the structure. Certain signaling events such as phosphorylation and molecule interplay may induce opening of the helix bundle. Such conformational change is proposed to precede departure of FAK from focal adhesions, which starts focal adhesion turnover.

About this Structure

1KTM is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase., Liu G, Guibao CD, Zheng J, Mol Cell Biol. 2002 Apr;22(8):2751-60. PMID:11909967 Page seeded by OCA on Fri May 2 23:09:29 2008

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