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4zjg

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Current revision (07:30, 18 May 2023) (edit) (undo)
 
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==Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning domains MG0-NIE-MG1.==
==Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning domains MG0-NIE-MG1.==
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<StructureSection load='4zjg' size='340' side='right' caption='[[4zjg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4zjg' size='340' side='right'caption='[[4zjg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zjg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zjg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjg OCA], [https://pdbe.org/4zjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zjg RCSB], [https://www.ebi.ac.uk/pdbsum/4zjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjg ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ziq|4ziq]], [[4ziu|4ziu]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yfhM, b2520, JW2504 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjg OCA], [http://pdbe.org/4zjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjg RCSB], [http://www.ebi.ac.uk/pdbsum/4zjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjg ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A2MG_ECOLI A2MG_ECOLI] Protects the bacterial cell from host peptidases (PubMed:18697741, PubMed:26143919, PubMed:26100869). Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase (PubMed:26143919, PubMed:26100869). Trapped peptidases are still active except against very large substrates (PubMed:26100869). May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases (PubMed:26100869).<ref>PMID:18697741</ref> <ref>PMID:26100869</ref> <ref>PMID:26143919</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Arede, P]]
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[[Category: Large Structures]]
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[[Category: Caston, J R]]
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[[Category: Arede P]]
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[[Category: Duquerroy, S]]
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[[Category: Caston JR]]
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[[Category: Garcia-Ferrer, I]]
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[[Category: Duquerroy S]]
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[[Category: Gomez-Blanco, J]]
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[[Category: Garcia-Ferrer I]]
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[[Category: Gomis-Ruth, X F]]
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[[Category: Gomez-Blanco J]]
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[[Category: Goulas, T]]
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[[Category: Gomis-Ruth XF]]
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[[Category: Luque, D]]
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[[Category: Goulas T]]
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[[Category: Bacterial pan-proteinase inhibitor]]
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[[Category: Luque D]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning domains MG0-NIE-MG1.

PDB ID 4zjg

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