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4zlr

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==Structure of the Brat-NHL domain bound to consensus RNA motif==
==Structure of the Brat-NHL domain bound to consensus RNA motif==
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<StructureSection load='4zlr' size='340' side='right' caption='[[4zlr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4zlr' size='340' side='right'caption='[[4zlr]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zlr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zlr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZLR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">brat, CG10719 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlr OCA], [https://pdbe.org/4zlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zlr RCSB], [https://www.ebi.ac.uk/pdbsum/4zlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlr OCA], [http://pdbe.org/4zlr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zlr RCSB], [http://www.ebi.ac.uk/pdbsum/4zlr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME]] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
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[https://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Jakob, L]]
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[[Category: Large Structures]]
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[[Category: Loedige, I]]
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[[Category: Synthetic construct]]
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[[Category: Meister, G]]
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[[Category: Jakob L]]
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[[Category: Stotz, M]]
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[[Category: Loedige I]]
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[[Category: Treiber, N]]
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[[Category: Meister G]]
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[[Category: Treiber, T]]
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[[Category: Stotz M]]
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[[Category: Beta-propeller]]
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[[Category: Treiber N]]
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[[Category: Nhl-domain]]
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[[Category: Treiber T]]
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[[Category: Rna binding]]
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[[Category: Translation]]
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[[Category: Translational repressor]]
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Revision as of 07:32, 18 May 2023

Structure of the Brat-NHL domain bound to consensus RNA motif

PDB ID 4zlr

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