4zpe

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4zpe' size='340' side='right'caption='[[4zpe]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4zpe' size='340' side='right'caption='[[4zpe]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4zpe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPE FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4zpe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPE FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4QA:4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-8-[3-(PROPAN-2-YLOXY)BENZYL]-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-2-ONE'>4QA</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4QA:4-(CYCLOHEXYLAMINO)-1-(3-FLUOROPHENYL)-8-[3-(PROPAN-2-YLOXY)BENZYL]-1,3,8-TRIAZASPIRO[4.5]DEC-3-EN-2-ONE'>4QA</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fkt|3fkt]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpe OCA], [https://pdbe.org/4zpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpe RCSB], [https://www.ebi.ac.uk/pdbsum/4zpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpe ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpe OCA], [http://pdbe.org/4zpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpe RCSB], [http://www.ebi.ac.uk/pdbsum/4zpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpe ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 28: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Memapsin 2]]
+
[[Category: Orth P]]
-
[[Category: Orth, P]]
+
-
[[Category: Alzheimer disease]]
+
-
[[Category: Amyloid beta-peptide]]
+
-
[[Category: Amyloid precursor protein secretase]]
+
-
[[Category: Aspartic acid endopeptidase]]
+
-
[[Category: Binding site]]
+
-
[[Category: Drug design]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Model]]
+
-
[[Category: Molecular]]
+
-
[[Category: Protease inhibitor]]
+
-
[[Category: Structure-activity relationship]]
+
-
[[Category: Transgenic]]
+

Revision as of 07:37, 18 May 2023

BACE1 in complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one

PDB ID 4zpe

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zpe"
Personal tools