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4zqg

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<StructureSection load='4zqg' size='340' side='right'caption='[[4zqg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4zqg' size='340' side='right'caption='[[4zqg]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zqg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"mikrokkokus_catarrhalis"_(sic)_frosch_and_kolle_in_flugge_1896 "mikrokkokus catarrhalis" (sic) frosch and kolle in flugge 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zqg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moraxella_catarrhalis Moraxella catarrhalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOM:3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC+ACID'>FOM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOM:3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC+ACID'>FOM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dxr, DR90_1378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=480 "Mikrokkokus catarrhalis" (sic) Frosch and Kolle in Flugge 1896])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqg OCA], [https://pdbe.org/4zqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqg RCSB], [https://www.ebi.ac.uk/pdbsum/4zqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqg ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqg OCA], [http://pdbe.org/4zqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqg RCSB], [http://www.ebi.ac.uk/pdbsum/4zqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqg ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D5VAW2_MORCB D5VAW2_MORCB] Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]
==See Also==
==See Also==
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*[[DXP reductoisomerase|DXP reductoisomerase]]
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*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Birkinshaw, R W]]
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[[Category: Moraxella catarrhalis]]
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[[Category: Brady, R L]]
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[[Category: Birkinshaw RW]]
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[[Category: Fosmidomycin]]
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[[Category: Brady RL]]
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[[Category: Mep pathway]]
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[[Category: Nadh]]
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[[Category: Oxidoreductase]]
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[[Category: Reductoisomerase]]
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Revision as of 07:37, 18 May 2023

Crystal structure of the Moraxella catarrhalis DOX-P Reductoisomerase in complex with NADH, fosmidomycin and magnesium

PDB ID 4zqg

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