1kut

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[[Image:1kut.gif|left|200px]]
[[Image:1kut.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1kut |SIZE=350|CAPTION= <scene name='initialview01'>1kut</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1kut", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TM1243 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01415 SAICAR_synt_Tm]</span>
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{{STRUCTURE_1kut| PDB=1kut | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kut OCA], [http://www.ebi.ac.uk/pdbsum/1kut PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kut RCSB]</span>
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'''Structural Genomics, Protein TM1243, (SAICAR synthetase)'''
'''Structural Genomics, Protein TM1243, (SAICAR synthetase)'''
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[[Category: Skarina, T.]]
[[Category: Skarina, T.]]
[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
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[[Category: mcsg]]
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[[Category: Mcsg]]
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[[Category: midwest center for structural genomic]]
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[[Category: Midwest center for structural genomic]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: saicar synthetase]]
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[[Category: Saicar synthetase]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:11:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:53:48 2008''
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Revision as of 20:11, 2 May 2008

Image:1kut.gif

Template:STRUCTURE 1kut

Structural Genomics, Protein TM1243, (SAICAR synthetase)


Overview

As a part of a structural genomics program, the 2.2 angstroms resolution crystal structure of the PurC gene product from Thermotoga maritima has been solved. This 26.2 kDa protein belongs to the phophoribosylaminoimidazole-succinocarboxamide or SAICAR synthase family of enzymes, the members of which are involved in de novo purine biosynthesis. SAICAR synthase can be divided into three subdomains: two alpha+beta regions exhibiting structural homology with ATP-binding proteins and a carboxy-terminal subdomain of two alpha-helices. The asymmetric unit contains two copies of the protein which are covalently linked by a disulfide bond between Cys126(A) and Cys126(B). This 230-amino-acid protein exhibits high structural homology with SAICAR synthase from baker's yeast. The protein structure is described and compared with that of the ATP-SAICAR synthase complex from yeast.

About this Structure

1KUT is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer., Zhang R, Skarina T, Evdokimova E, Edwards A, Savchenko A, Laskowski R, Cuff ME, Joachimiak A, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):335-9. Epub 2006 Mar 25. PMID:16582479 Page seeded by OCA on Fri May 2 23:11:33 2008

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OCA

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