7y6e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of sDscam FNIII23 domains, isoform Beta2v6== | |
| + | <StructureSection load='7y6e' size='340' side='right'caption='[[7y6e]], [[Resolution|resolution]] 3.03Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7y6e]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Chelicerata Chelicerata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y6E FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y6e OCA], [https://pdbe.org/7y6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y6e RCSB], [https://www.ebi.ac.uk/pdbsum/7y6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y6e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A161FW14_MESMA A0A161FW14_MESMA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscam family and vertebrate Pcdh family are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data and functional assays. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam. | ||
| - | + | Structural basis for the self-recognition of sDSCAM in Chelicerata.,Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q Nat Commun. 2023 May 2;14(1):2522. doi: 10.1038/s41467-023-38205-1. PMID:37130844<ref>PMID:37130844</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 7y6e" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chelicerata]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen Q]] | ||
| + | [[Category: Cheng J]] | ||
| + | [[Category: Yu Y]] | ||
Revision as of 03:59, 25 May 2023
Crystal structure of sDscam FNIII23 domains, isoform Beta2v6
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Categories: Chelicerata | Large Structures | Chen Q | Cheng J | Yu Y
