2n77

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Current revision (04:31, 25 May 2023) (edit) (undo)
 
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==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==
==NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin==
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<StructureSection load='2n77' size='340' side='right'caption='[[2n77]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2n77' size='340' side='right'caption='[[2n77]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N77 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2n77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N77 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PCP4, PEP19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [https://pdbe.org/2n77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [https://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n77 OCA], [https://pdbe.org/2n77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n77 RCSB], [https://www.ebi.ac.uk/pdbsum/2n77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n77 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PCP4_HUMAN PCP4_HUMAN]] Probable regulator of calmodulin signaling.<ref>PMID:19106096</ref>
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Putkey, J A]]
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[[Category: Putkey JA]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Intrinsically disordered]]
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[[Category: Signaling protein]]
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[[Category: Structural transition]]
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Current revision

NMR solution structure of a complex of PEP-19 bound to the C-domain of apo calmodulin

PDB ID 2n77

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