1k9i

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(New page: 200px<br /> <applet load="1k9i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k9i, resolution 2.50&Aring;" /> '''Complex of DC-SIGN ...)
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Revision as of 15:42, 12 November 2007

Image:1k9i.gif

1k9i, resolution 2.50Å

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Complex of DC-SIGN and GlcNAc2Man3

Overview

Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3), grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of, dendritic cells, mediates the initial interaction of dendritic cells with, T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor, found on the endothelium of liver sinusoids, placental capillaries, and, lymph nodes, bind to oligosaccharides that are present on the envelope of, human immunodeficiency virus (HIV), an interaction that strongly promotes, viral infection of T cells. Crystal structures of carbohydrate-recognition, domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in, combination with binding studies, reveal that these receptors selectively, recognize endogenous high-mannose oligosaccharides and may represent a new, avenue for developing HIV prophylactics.

About this Structure

1K9I is a Single protein structure of sequence from Homo sapiens with CA as ligand. Full crystallographic information is available from OCA.

Reference

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:11739956

Page seeded by OCA on Mon Nov 12 17:48:45 2007

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