1kw4

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[[Image:1kw4.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1kw4", creates the "Structure Box" on the page.
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{{STRUCTURE_1kw4| PDB=1kw4 | SCENE= }}
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|RELATEDENTRY=[[1ji7|1JI7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kw4 OCA], [http://www.ebi.ac.uk/pdbsum/1kw4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kw4 RCSB]</span>
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'''Polyhomeotic SAM domain structure'''
'''Polyhomeotic SAM domain structure'''
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[[Category: Kim, C A.]]
[[Category: Kim, C A.]]
[[Category: Pilpa, R M.]]
[[Category: Pilpa, R M.]]
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[[Category: polycomb group]]
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[[Category: Polycomb group]]
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[[Category: polymer]]
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[[Category: Polymer]]
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[[Category: sam domain]]
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[[Category: Sam domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:14:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:54:23 2008''
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Revision as of 20:14, 2 May 2008

Image:1kw4.jpg

Template:STRUCTURE 1kw4

Polyhomeotic SAM domain structure


Overview

The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of another transcriptional repressor, TEL. The formation of these polymer structures by SAM domains in two divergent repressors suggests a conserved mode of repression involving a higher order chromatin structure.

About this Structure

1KW4 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

The SAM domain of polyhomeotic forms a helical polymer., Kim CA, Gingery M, Pilpa RM, Bowie JU, Nat Struct Biol. 2002 Jun;9(6):453-7. PMID:11992127 Page seeded by OCA on Fri May 2 23:14:20 2008

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