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| | <SX load='5a6f' size='340' side='right' viewer='molstar' caption='[[5a6f]], [[Resolution|resolution]] 4.20Å' scene=''> | | <SX load='5a6f' size='340' side='right' viewer='molstar' caption='[[5a6f]], [[Resolution|resolution]] 4.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5a6f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A6F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5A6F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5a6f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A6F FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a6f OCA], [https://pdbe.org/5a6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a6f RCSB], [https://www.ebi.ac.uk/pdbsum/5a6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a6f ProSAT]</span></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a6e|5a6e]], [[5a6g|5a6g]]</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5a6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a6f OCA], [http://pdbe.org/5a6f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a6f RCSB], [http://www.ebi.ac.uk/pdbsum/5a6f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a6f ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/KCNT1_CHICK KCNT1_CHICK]] Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium. | + | [https://www.uniprot.org/uniprot/KCNT1_CHICK KCNT1_CHICK] Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </SX> | | </SX> |
| - | [[Category: Chick]] | + | [[Category: Gallus gallus]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Hite, R K]] | + | [[Category: Hite RK]] |
| - | [[Category: Hsuing, Y]] | + | [[Category: Hsuing Y]] |
| - | [[Category: Li, Z]] | + | [[Category: Li Z]] |
| - | [[Category: MacKinnon, R]] | + | [[Category: MacKinnon R]] |
| - | [[Category: Walz, T]] | + | [[Category: Walz T]] |
| - | [[Category: Yuan, P]] | + | [[Category: Yuan P]] |
| - | [[Category: Ion channel]]
| + | |
| - | [[Category: Potassium channel]]
| + | |
| - | [[Category: Transport]]
| + | |
| Structural highlights
Function
KCNT1_CHICK Generates outwardly rectifying currents that are suppressed by elevation of intracellular calcium.
Publication Abstract from PubMed
Na+-activated K+ channels are members of the Slo family of large conductance K+ channels that are widely expressed in the brain, where their opening regulates neuronal excitability. These channels fulfil a number of biological roles and have intriguing biophysical properties, including conductance levels that are ten times those of most other K+ channels and gating sensitivity to intracellular Na+. Here we present the structure of a complete Na+-activated K+ channel, chicken Slo2.2, in the Na+-free state, determined by cryo-electron microscopy at a nominal resolution of 4.5 angstroms. The channel is composed of a large cytoplasmic gating ring, in which resides the Na+-binding site and a transmembrane domain that closely resembles voltage-gated K+ channels. In the structure, the cytoplasmic domain adopts a closed conformation and the ion conduction pore is also closed. The structure reveals features that can explain the unusually high conductance of Slo channels and how contraction of the cytoplasmic gating ring closes the pore.
Cryo-electron microscopy structure of the Slo2.2 Na-activated K channel.,Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R Nature. 2015 Oct 5. doi: 10.1038/nature14958. PMID:26436452[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R. Cryo-electron microscopy structure of the Slo2.2 Na-activated K channel. Nature. 2015 Oct 5. doi: 10.1038/nature14958. PMID:26436452 doi:http://dx.doi.org/10.1038/nature14958
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