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5a6p

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Revision as of 04:41, 25 May 2023

Heavy metal associated domain of NLR-type immune receptor Pikp1 from rice (Oryza sativa)

Structural highlights

5a6p is a 2 chain structure with sequence from Oryza sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

E9KPB5_ORYSJ

Publication Abstract from PubMed

Plants have evolved intracellular immune receptors to detect pathogen proteins known as effectors. How these immune receptors detect effectors remains poorly understood. Here we describe the structural basis for direct recognition of AVR-Pik, an effector from the rice blast pathogen, by the rice intracellular NLR immune receptor Pik. AVR-PikD binds a dimer of the Pikp-1 HMA integrated domain with nanomolar affinity. The crystal structure of the Pikp-HMA/AVR-PikD complex enabled design of mutations to alter protein interaction in yeast and in vitro, and perturb effector-mediated response both in a rice cultivar containing Pikp and upon expression of AVR-PikD and Pikp in the model plant Nicotiana benthamiana. These data reveal the molecular details of a recognition event, mediated by a novel integrated domain in an NLR, which initiates a plant immune response and resistance to rice blast disease. Such studies underpin novel opportunities for engineering disease resistance to plant pathogens in staple food crops.

Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor.,Maqbool A, Saitoh H, Franceschetti M, Stevenson C, Uemura A, Kanzaki H, Kamoun S, Terauchi R, Banfield MJ Elife. 2015 Aug 25;4. doi: 10.7554/eLife.08709. PMID:26304198^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Maqbool A, Saitoh H, Franceschetti M, Stevenson C, Uemura A, Kanzaki H, Kamoun S, Terauchi R, Banfield MJ. Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor. Elife. 2015 Aug 25;4. doi: 10.7554/eLife.08709. PMID:26304198 doi:http://dx.doi.org/10.7554/eLife.08709

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5a6p"

@@ Line 3: / Line 3: @@
 <StructureSection load='5a6p' size='340' side='right'caption='[[5a6p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5a6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Orysa Orysa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A6P FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5a6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa Oryza sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A6P FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a6w|5a6w]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a6p OCA], [https://pdbe.org/5a6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a6p RCSB], [https://www.ebi.ac.uk/pdbsum/5a6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a6p ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a6p OCA], [http://pdbe.org/5a6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a6p RCSB], [http://www.ebi.ac.uk/pdbsum/5a6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a6p ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/E9KPB5_ORYSJ E9KPB5_ORYSJ]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 22: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Orysa]]
+[[Category: Oryza sativa]]
-[[Category: Banfield, M J]]
+[[Category: Banfield MJ]]
-[[Category: Franceschetti, M]]
+[[Category: Franceschetti M]]
-[[Category: Kamoun, S]]
+[[Category: Kamoun S]]
-[[Category: Kanzaki, H]]
+[[Category: Kanzaki H]]
-[[Category: Maqbool, A]]
+[[Category: Maqbool A]]
-[[Category: Saitoh, H]]
+[[Category: Saitoh H]]
-[[Category: Stevenson, C E]]
+[[Category: Stevenson CE]]
-[[Category: Terauchi, R]]
+[[Category: Terauchi R]]
-[[Category: Uemura, A]]
+[[Category: Uemura A]]
-[[Category: Heavy metal associated domain]]
-[[Category: Immune system]]
-[[Category: Nlr immune receptor]]

5a6p

From Proteopedia

Revision as of 04:41, 25 May 2023

Heavy metal associated domain of NLR-type immune receptor Pikp1 from rice (Oryza sativa)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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