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5a8g

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<StructureSection load='5a8g' size='340' side='right'caption='[[5a8g]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='5a8g' size='340' side='right'caption='[[5a8g]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A8G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a8g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A8G FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPF:N-(1-CARBOXY-2-FLUORO-ETHENYL)+LYSINE'>KPF</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KPF:N-(1-CARBOXY-2-FLUORO-ETHENYL)+LYSINE'>KPF</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a8g OCA], [https://pdbe.org/5a8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a8g RCSB], [https://www.ebi.ac.uk/pdbsum/5a8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a8g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a8g OCA], [http://pdbe.org/5a8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a8g RCSB], [http://www.ebi.ac.uk/pdbsum/5a8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a8g ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NANA_STAA8 NANA_STAA8]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).
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[https://www.uniprot.org/uniprot/NANA_STAA8 NANA_STAA8] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5a8g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5a8g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: N-acetylneuraminate lyase]]
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[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
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[[Category: Staa8]]
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[[Category: Berry A]]
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[[Category: Berry, A]]
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[[Category: Daniels AD]]
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[[Category: Daniels, A D]]
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[[Category: Harman T]]
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[[Category: Harman, T]]
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[[Category: Lebel T]]
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[[Category: Lebel, T]]
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[[Category: Mulholland K]]
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[[Category: Mulholland, K]]
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[[Category: Nelson A]]
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[[Category: Nelson, A]]
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[[Category: Pearson AR]]
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[[Category: Pearson, A R]]
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[[Category: Stockwell J]]
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[[Category: Stockwell, J]]
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[[Category: Trinh CH]]
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[[Category: Trinh, C H]]
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[[Category: Windle CL]]
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[[Category: Windle, C L]]
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[[Category: Woodhall T]]
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[[Category: Woodhall, T]]
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[[Category: Lyase]]
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Revision as of 04:45, 25 May 2023

Crystal structure of the wild-type Staphylococcus aureus N- acetylneurminic acid lyase in complex with fluoropyruvate

PDB ID 5a8g

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