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| | <StructureSection load='5a9v' size='340' side='right'caption='[[5a9v]], [[Resolution|resolution]] 3.31Å' scene=''> | | <StructureSection load='5a9v' size='340' side='right'caption='[[5a9v]], [[Resolution|resolution]] 3.31Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5a9v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A9V FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5a9v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A9V FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a9w|5a9w]], [[5a9x|5a9x]], [[5a9y|5a9y]], [[5a9z|5a9z]], [[5aa0|5aa0]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9v OCA], [https://pdbe.org/5a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a9v RCSB], [https://www.ebi.ac.uk/pdbsum/5a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a9v ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9v OCA], [http://pdbe.org/5a9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a9v RCSB], [http://www.ebi.ac.uk/pdbsum/5a9v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a9v ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/B7MHF0_ECO45 B7MHF0_ECO45] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus coli migula 1895]] | + | [[Category: Escherichia coli]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Chen, Y]] | + | [[Category: Chen Y]] |
| - | [[Category: Ero, R]] | + | [[Category: Ero R]] |
| - | [[Category: Gao, Y]] | + | [[Category: Gao Y]] |
| - | [[Category: Kumar, V]] | + | [[Category: Kumar V]] |
| - | [[Category: Li, Z]] | + | [[Category: Li Z]] |
| - | [[Category: Ribosomal protein]]
| + | |
| - | [[Category: Ribosome]]
| + | |
| - | [[Category: Translational gtpase factor]]
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| Structural highlights
Function
B7MHF0_ECO45
Publication Abstract from PubMed
BPI-inducible protein A (BipA) is a member of the family of ribosome-dependent translational GTPase (trGTPase) factors along with elongation factors G and 4 (EF-G and EF4). Despite being highly conserved in bacteria and playing a critical role in coordinating cellular responses to environmental changes, its structures (isolated and ribosome bound) remain elusive. Here, we present the crystal structures of apo form and GTP analog, GDP, and guanosine-3',5'-bisdiphosphate (ppGpp)-bound BipA. In addition to having a distinctive domain arrangement, the C-terminal domain of BipA has a unique fold. Furthermore, we report the cryo-electron microscopy structure of BipA bound to the ribosome in its active GTP form and elucidate the unique structural attributes of BipA interactions with the ribosome and A-site tRNA in the light of its possible function in regulating translation.
Structure of BipA in GTP form bound to the ratcheted ribosome.,Kumar V, Chen Y, Ero R, Ahmed T, Tan J, Li Z, Wong AS, Bhushan S, Gao YG Proc Natl Acad Sci U S A. 2015 Aug 17. pii: 201513216. PMID:26283392[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Kumar V, Chen Y, Ero R, Ahmed T, Tan J, Li Z, Wong AS, Bhushan S, Gao YG. Structure of BipA in GTP form bound to the ratcheted ribosome. Proc Natl Acad Sci U S A. 2015 Aug 17. pii: 201513216. PMID:26283392 doi:http://dx.doi.org/10.1073/pnas.1513216112
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