1kwi

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[[Image:1kwi.jpg|left|200px]]
[[Image:1kwi.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1kwi", creates the "Structure Box" on the page.
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|GENE= pg3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])
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{{STRUCTURE_1kwi| PDB=1kwi | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kwi OCA], [http://www.ebi.ac.uk/pdbsum/1kwi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kwi RCSB]</span>
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'''Crystal Structure Analysis of the Cathelicidin Motif of Protegrins'''
'''Crystal Structure Analysis of the Cathelicidin Motif of Protegrins'''
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[[Category: Sanchez, J F.]]
[[Category: Sanchez, J F.]]
[[Category: Strub, M P.]]
[[Category: Strub, M P.]]
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[[Category: cathelicidin motif]]
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[[Category: Cathelicidin motif]]
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[[Category: disulfide]]
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[[Category: Disulfide]]
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[[Category: mad]]
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[[Category: Mad]]
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[[Category: protegrin]]
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[[Category: Protegrin]]
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[[Category: selenocystine]]
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[[Category: Selenocystine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:15:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:54:39 2008''
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Revision as of 20:15, 2 May 2008

Image:1kwi.jpg

Template:STRUCTURE 1kwi

Crystal Structure Analysis of the Cathelicidin Motif of Protegrins


Overview

Cathelicidins are a family of antimicrobial proteins isolated from leucocytes and epithelia cells that contribute to the innate host defense mechanisms in mammalians. Located in the C-terminal part of the holoprotein, the cathelicidin-derived antimicrobial peptide is liberated by a specific protease cleavage. Here, we report the X-ray structure of the cathelicidin motif of protegrin-3 solved by MAD phasing using the selenocysteine-labeled protein. Its overall structure represents a fold homologous to the cystatin family and adopts two native states, a monomer, and a domain-swapped dimer. This crystal structure is the first example of a structural characterization of the highly conserved cathelicidin motif and thus provides insights into the possible mechanism of activation of the antimicrobial protegrin peptide.

About this Structure

1KWI is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein., Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C, Structure. 2002 Oct;10(10):1363-70. PMID:12377122 Page seeded by OCA on Fri May 2 23:15:27 2008

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