5abj

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<StructureSection load='5abj' size='340' side='right'caption='[[5abj]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='5abj' size='340' side='right'caption='[[5abj]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cv-a16 Cv-a16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5abj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_A16 Coxsackievirus A16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ABJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YM2:1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE'>YM2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [http://pdbe.org/5abj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [http://www.ebi.ac.uk/pdbsum/5abj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5abj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5abj OCA], [https://pdbe.org/5abj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5abj RCSB], [https://www.ebi.ac.uk/pdbsum/5abj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5abj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO]] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
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[https://www.uniprot.org/uniprot/I3W9E1_9ENTO I3W9E1_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5abj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5abj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cv-a16]]
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[[Category: Coxsackievirus A16]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Colibus, L De]]
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[[Category: De Colibus L]]
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[[Category: Fry, E E]]
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[[Category: Fry EE]]
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[[Category: Grimes, J M]]
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[[Category: Grimes JM]]
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[[Category: Leyssen, P]]
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[[Category: Leyssen P]]
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[[Category: Neyts, J]]
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[[Category: Neyts J]]
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[[Category: Puerstinger, G]]
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[[Category: Puerstinger G]]
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[[Category: Rao, Z]]
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[[Category: Rao Z]]
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[[Category: Ren, J]]
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[[Category: Ren J]]
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[[Category: Spyrou, J A.B]]
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[[Category: Spyrou JAB]]
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[[Category: Stuart, D I]]
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[[Category: Stuart DI]]
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[[Category: Tijsma, A]]
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[[Category: Tijsma A]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Inhibitor]]
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[[Category: Virus]]
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Revision as of 04:49, 25 May 2023

Structure of Coxsackievirus A16 in complex with GPP3

PDB ID 5abj

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