1kws

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1kws.jpg|left|200px]]
[[Image:1kws.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1kws |SIZE=350|CAPTION= <scene name='initialview01'>1kws</scene>, resolution 2.10&Aring;
+
The line below this paragraph, containing "STRUCTURE_1kws", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UGA:URIDINE-5&#39;-DIPHOSPHATE-GLUCURONIC+ACID'>UGA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1kws| PDB=1kws | SCENE= }}
-
|RELATEDENTRY=[[1fgg|1FGG]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kws OCA], [http://www.ebi.ac.uk/pdbsum/1kws PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kws RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF BETA1,3-GLUCURONYLTRANSFERASE I IN COMPLEX WITH THE ACTIVE UDP-GLCUA DONOR'''
'''CRYSTAL STRUCTURE OF BETA1,3-GLUCURONYLTRANSFERASE I IN COMPLEX WITH THE ACTIVE UDP-GLCUA DONOR'''
Line 28: Line 25:
[[Category: Negishi, M.]]
[[Category: Negishi, M.]]
[[Category: Pedersen, L C.]]
[[Category: Pedersen, L C.]]
-
[[Category: dxd]]
+
[[Category: Dxd]]
-
[[Category: ntp binding domain]]
+
[[Category: Ntp binding domain]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:15:57 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:54:44 2008''
+

Revision as of 20:16, 2 May 2008

Image:1kws.jpg

Template:STRUCTURE 1kws

CRYSTAL STRUCTURE OF BETA1,3-GLUCURONYLTRANSFERASE I IN COMPLEX WITH THE ACTIVE UDP-GLCUA DONOR


Overview

Beta1,3-glucuronyltransferase (GlcAT-I) is an essential enzyme involved in heparan sulfate and chondroitin sulfate biosynthesis. GlcAT-I is an inverting glycosyltransferase that catalyzes the transfer of glucuronic acid (GlcUA) to the common growing linker region Galbeta1-3Galbeta1-4Xyl that is attached to a serine side chain of a core protein. Previously the structure of GlcAT-I has been solved in the presence of the donor product UDP and an acceptor analog Galbeta1-3Galbeta1-4Xyl (Pedersen, L. C., Tsuchida, K., Kitagawa, H., Sugahara, K., Darden, T. A. & Negishi, M. (2000) J. Biol. Chem. 275, 34580-34585). Here we report the x-ray crystal structure of GlcAT-I in complex with the complete donor UDP-GlcUA, thereby providing structures of an inverting glycosyltransferase in which both the complete donor and acceptor substrates are present in the active site. This structure supports the in-line displacement reaction mechanism previously proposed. It also provides information on the essential amino acid residues that determine donor substrate specificity.

About this Structure

1KWS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA., Pedersen LC, Darden TA, Negishi M, J Biol Chem. 2002 Jun 14;277(24):21869-73. Epub 2002 Apr 11. PMID:11950836 Page seeded by OCA on Fri May 2 23:15:57 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1kws"
Personal tools