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5aga

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Current revision (04:57, 25 May 2023) (edit) (undo)
 
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<StructureSection load='5aga' size='340' side='right'caption='[[5aga]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='5aga' size='340' side='right'caption='[[5aga]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5aga]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5aga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aga OCA], [https://pdbe.org/5aga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aga RCSB], [https://www.ebi.ac.uk/pdbsum/5aga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aga ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aga OCA], [http://pdbe.org/5aga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aga RCSB], [http://www.ebi.ac.uk/pdbsum/5aga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aga ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN]] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref>
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[https://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aitkenhead, H]]
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[[Category: Aitkenhead H]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Cooper, C D.O]]
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[[Category: Cooper CDO]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O]]
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[[Category: Kupinska K]]
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[[Category: Kupinska, K]]
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[[Category: Newman JA]]
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[[Category: Newman, J A]]
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[[Category: Pinkas DM]]
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[[Category: Pinkas, D M]]
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[[Category: Von Delft F]]
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[[Category: Dna repair]]
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[[Category: Polq]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Helicase domain of human DNA polymerase theta in complex with AMPPNP

PDB ID 5aga

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