1kxg

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[[Image:1kxg.gif|left|200px]]
[[Image:1kxg.gif|left|200px]]
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{{Structure
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|PDB= 1kxg |SIZE=350|CAPTION= <scene name='initialview01'>1kxg</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1kxg", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1kxg| PDB=1kxg | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxg OCA], [http://www.ebi.ac.uk/pdbsum/1kxg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kxg RCSB]</span>
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'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''
'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''
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[[Category: Oren, D A.]]
[[Category: Oren, D A.]]
[[Category: Volovik, Y.]]
[[Category: Volovik, Y.]]
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[[Category: baff]]
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[[Category: Baff]]
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[[Category: beta-sandwich]]
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[[Category: Beta-sandwich]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: jellyroll]]
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[[Category: Jellyroll]]
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[[Category: tall-1]]
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[[Category: Tall-1]]
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[[Category: thank]]
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[[Category: Thank]]
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[[Category: tnf superfamily]]
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[[Category: Tnf superfamily]]
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[[Category: ztnf4]]
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[[Category: Ztnf4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:17:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:55:00 2008''
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Revision as of 20:17, 2 May 2008

Image:1kxg.gif

Template:STRUCTURE 1kxg

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.


Overview

B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity.

About this Structure

1KXG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:11862220 Page seeded by OCA on Fri May 2 23:17:29 2008

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