1kxu
From Proteopedia
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[[Image:1kxu.gif|left|200px]] | [[Image:1kxu.gif|left|200px]] | ||
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'''CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE''' | '''CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE''' | ||
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[[Category: Kim, S H.]] | [[Category: Kim, S H.]] | ||
[[Category: Morgan, D O.]] | [[Category: Morgan, D O.]] | ||
| - | [[Category: | + | [[Category: Alpha-helical structure]] |
| - | [[Category: | + | [[Category: Cell cycle]] |
| - | [[Category: | + | [[Category: Cell division]] |
| - | [[Category: | + | [[Category: Cyclin]] |
| - | [[Category: | + | [[Category: Nuclear protein]] |
| - | [[Category: | + | [[Category: Regulatory protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:18:15 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:18, 2 May 2008
CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Overview
Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at a specific threonine residue. Vertebrate CAK contains two key components: a kinase subunit with homology to its substrate CDKs and a regulatory subunit with homology to cyclins. We have determined the X-ray crystal structure of the regulatory subunit of CAK, cyclin H, at 2.6 A resolution. Cyclin H contains two alpha-helical core domains with a fold similar to that of cyclin A, a regulatory subunit of CAK substrate CDK2, and of TFIIB, a transcription factor. Outside of the core domains, the N- and C-terminal regions of the three structures are completely different. The conformational differences between cyclin H and A structures may reflect functional differences between the two cyclins.
About this Structure
1KXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase., Kim KK, Chamberlin HM, Morgan DO, Kim SH, Nat Struct Biol. 1996 Oct;3(10):849-55. PMID:8836101 Page seeded by OCA on Fri May 2 23:18:15 2008
