7yni
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human SGLT1-MAP17 complex bound with substrate 4D4FDG in the occluded conformation== | |
| - | + | <StructureSection load='7yni' size='340' side='right'caption='[[7yni]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YNI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KQC:(2R,3R,4R,5S,6R)-5-fluoranyl-6-(hydroxymethyl)oxane-2,3,4-triol'>KQC</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yni OCA], [https://pdbe.org/7yni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yni RCSB], [https://www.ebi.ac.uk/pdbsum/7yni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yni ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SC5A1_HUMAN SC5A1_HUMAN] Glucose-galactose malabsorption. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SC5A1_HUMAN SC5A1_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:35077764, PubMed:8563765, PubMed:34880492). Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (PubMed:8563765) (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception (PubMed:28974690). Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine.[UniProtKB:Q8C3K6]<ref>PMID:14695256</ref> <ref>PMID:20980548</ref> <ref>PMID:26945065</ref> <ref>PMID:28974690</ref> <ref>PMID:34880492</ref> <ref>PMID:35077764</ref> <ref>PMID:8563765</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen L]] | ||
| + | [[Category: Cui W]] | ||
| + | [[Category: Niu Y]] | ||
Revision as of 05:36, 31 May 2023
Structure of human SGLT1-MAP17 complex bound with substrate 4D4FDG in the occluded conformation
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Categories: Homo sapiens | Large Structures | Chen L | Cui W | Niu Y
