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8ce2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of the adduct formed upon reaction of a B-DNA double helical dodecamer with dirhodium tetraacetate== | |
| + | <StructureSection load='8ce2' size='340' side='right'caption='[[8ce2]], [[Resolution|resolution]] 1.24Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8ce2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CE2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RH:RHODIUM'>RH</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ce2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ce2 OCA], [https://pdbe.org/8ce2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ce2 RCSB], [https://www.ebi.ac.uk/pdbsum/8ce2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ce2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The reaction of the cytotoxic compound dirhodium tetraacetate with a B-DNA double helical dodecamer was studied by X-ray crystallography and mass spectrometry. The structure of the dirhodium/DNA adduct reveals a dimetallic center binding to an adenine via axial coordination. Complementary information has been gained through ESI MS measurements. Comparison between the present data and those previously obtained for cisplatin indicates that the two metallodrugs react with this DNA dodecamer in a significantly different fashion. | ||
| - | + | Dirhodium tetraacetate binding to a B-DNA double helical dodecamer probed by X-ray crystallography and mass spectrometry.,Tito G, Troisi R, Ferraro G, Geri A, Massai L, Messori L, Sica F, Merlino A Dalton Trans. 2023 May 30;52(21):6992-6996. doi: 10.1039/d3dt00320e. PMID:37199244<ref>PMID:37199244</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Ferraro | + | <div class="pdbe-citations 8ce2" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: Sica | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Troisi | + | </StructureSection> |
| + | [[Category: DNA molecule]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ferraro G]] | ||
| + | [[Category: Merlino A]] | ||
| + | [[Category: Sica F]] | ||
| + | [[Category: Tito G]] | ||
| + | [[Category: Troisi R]] | ||
Current revision
X-ray structure of the adduct formed upon reaction of a B-DNA double helical dodecamer with dirhodium tetraacetate
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Categories: DNA molecule | Large Structures | Ferraro G | Merlino A | Sica F | Tito G | Troisi R
