8gnk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of cytosol-facing, substrate-bound ratGAT1== | |
| - | + | <StructureSection load='8gnk' size='340' side='right'caption='[[8gnk]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8gnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GNK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gnk OCA], [https://pdbe.org/8gnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gnk RCSB], [https://www.ebi.ac.uk/pdbsum/8gnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gnk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SC6A1_RAT SC6A1_RAT] Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:1975955, PubMed:18054861). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (PubMed:18054861, PubMed:21775701). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (PubMed:18054861, PubMed:21775701). Also mediates sodium- and chloride-dependent transport of hypotaurine (By similarity).[UniProtKB:P31648]<ref>PMID:18054861</ref> <ref>PMID:1975955</ref> <ref>PMID:21775701</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Joseph D]] | ||
| + | [[Category: Nayak SR]] | ||
| + | [[Category: Penmatsa A]] | ||
Revision as of 05:44, 31 May 2023
CryoEM structure of cytosol-facing, substrate-bound ratGAT1
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