5az5
From Proteopedia
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<StructureSection load='5az5' size='340' side='right'caption='[[5az5]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='5az5' size='340' side='right'caption='[[5az5]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5az5]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5az5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AZ5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MBL:1-PENTYL-4-PHENYL-IMIDAZOL-2-AMINE'>MBL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MBL:1-PENTYL-4-PHENYL-IMIDAZOL-2-AMINE'>MBL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5az5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5az5 OCA], [https://pdbe.org/5az5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5az5 RCSB], [https://www.ebi.ac.uk/pdbsum/5az5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5az5 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref> |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ohto | + | [[Category: Ohto U]] |
| - | [[Category: Shimizu | + | [[Category: Shimizu T]] |
| - | [[Category: Tanji | + | [[Category: Tanji H]] |
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Current revision
Crystal structure of human TLR8 in complex with MB-343
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