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5b26

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Revision as of 06:36, 31 May 2023

Crystal structure of mouse SEL1L

Structural highlights

5b26 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SE1L1_MOUSE May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity).

Publication Abstract from PubMed

Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse SEL1L central domain comprising five Sel1-Like Repeats (SLR motifs 5 to 9; hereafter called SEL1L(cent)). Strikingly, SEL1L(cent) forms a homodimer with two-fold symmetry in a head-to-tail manner. Particularly, the SLR motif 9 plays an important role in dimer formation by adopting a domain-swapped structure and providing an extensive dimeric interface. We identified that the full-length SEL1L forms a self-oligomer through the SEL1L(cent) domain in mammalian cells. Furthermore, we discovered that the SLR-C, comprising SLR motifs 10 and 11, of SEL1L directly interacts with the N-terminus luminal loops of HRD1. Therefore, we propose that certain SLR motifs of SEL1L play a unique role in membrane bound ERAD machinery.

Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway.,Jeong H, Sim HJ, Song EK, Lee H, Ha SC, Jun Y, Park TJ, Lee C Sci Rep. 2016 Feb 9;6:20261. doi: 10.1038/srep20261. PMID:27064360^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Jeong H, Sim HJ, Song EK, Lee H, Ha SC, Jun Y, Park TJ, Lee C. Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway. Sci Rep. 2016 Feb 9;6:20261. doi: 10.1038/srep20261. PMID:27064360 doi:http://dx.doi.org/10.1038/srep20261

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5b26"

Categories: Large Structures | Mus musculus | Jeong H | Lee C

@@ Line 3: / Line 3: @@
 <StructureSection load='5b26' size='340' side='right'caption='[[5b26]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5b26]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B26 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5b26]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B26 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sel1l, Sel1h ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b26 OCA], [https://pdbe.org/5b26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b26 RCSB], [https://www.ebi.ac.uk/pdbsum/5b26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b26 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b26 OCA], [http://pdbe.org/5b26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b26 RCSB], [http://www.ebi.ac.uk/pdbsum/5b26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b26 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SE1L1_MOUSE SE1L1_MOUSE]] May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity).
+[https://www.uniprot.org/uniprot/SE1L1_MOUSE SE1L1_MOUSE] May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 22: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Jeong, H]]
+[[Category: Jeong H]]
-[[Category: Lee, C]]
+[[Category: Lee C]]
-[[Category: Erad]]
-[[Category: Sel1l]]
-[[Category: Signaling protein]]
-[[Category: Slr motif]]

5b26

From Proteopedia

Revision as of 06:36, 31 May 2023

Crystal structure of mouse SEL1L

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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