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Ion channels 3D structures

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Line 71: Line 71:
*Sodium channel; Domains – extracellular 30-157
*Sodium channel; Domains – extracellular 30-157
 +
**[[7dtd]] - hNaV 1.1 + hNav beta 4 – Cryo EM<br />
 +
**[[6agf]] - hNaV 1 + hNav 1.4 – Cryo EM<br />
**[[2kav]], [[2kbi]] – hNaV 1.2 C-terminal EF-hand domain – NMR<br />
**[[2kav]], [[2kbi]] – hNaV 1.2 C-terminal EF-hand domain – NMR<br />
 +
**[[7w77]], [[7w7f]] – hNaV 1.3 beta1+beta2 + hNaV type 3 subunit alpha – Cryo EM<br />
**[[5fdy]], [[5feb]] - hNaV 2 extracellular domain (mutant)<br />
**[[5fdy]], [[5feb]] - hNaV 2 extracellular domain (mutant)<br />
**[[6vrr]] - hNaV 2 (mutant)<br />
**[[6vrr]] - hNaV 2 (mutant)<br />
Line 77: Line 80:
**[[4mz2]] - hNaV 4 extracellular domain <br />
**[[4mz2]] - hNaV 4 extracellular domain <br />
**[[4mz3]], [[6vsv]] - hNaV 4 extracellular domain (mutant)<br />
**[[4mz3]], [[6vsv]] - hNaV 4 extracellular domain (mutant)<br />
-
**[[6bqn]] – hENaC ++g subunits – Cryo EM<br />
+
**[[6bqn]] – hENaC alpha+beta+gamma subunits – Cryo EM<br />
**[[7dtc]] – hNaV 1.5 (mutant) – Cryo EM<br />
**[[7dtc]] – hNaV 1.5 (mutant) – Cryo EM<br />
**[[7l83]] – hNaV 1.5 1597-1633 - NMR <br />
**[[7l83]] – hNaV 1.5 1597-1633 - NMR <br />
**[[8fhd]] – hNaV 1.6 – Cryo EM<br />
**[[8fhd]] – hNaV 1.6 – Cryo EM<br />
 +
**[[8gz1]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha – Cryo EM<br />
**[[7xvf]] – hNaV 1.7 (mutant) – Cryo EM<br />
**[[7xvf]] – hNaV 1.7 (mutant) – Cryo EM<br />
 +
**[[7w9l]], [[7w9t]] – hNaV 1.7 (mutant) + beta-1 + beta-2 – Cryo EM<br />
 +
**[[7w9k]] – hNaV 1.7 beta-1 + beta-2 – Cryo EM<br />
**[[7wfw]] – hNaV 1.8 – Cryo EM<br />
**[[7wfw]] – hNaV 1.8 – Cryo EM<br />
**[[7tj8]] – hNaV type 7 alpha – Cryo EM<br />
**[[7tj8]] – hNaV type 7 alpha – Cryo EM<br />
 +
**[[7tj9]] – hNaV type 7 alpha + beta-3 – Cryo EM<br />
**[[1byy]] – rNaCh IIA inactivation fragment<br />
**[[1byy]] – rNaCh IIA inactivation fragment<br />
**[[5jr0]] – rNaV 1.4 <br />
**[[5jr0]] – rNaV 1.4 <br />
Line 90: Line 97:
**[[1qg9]] – raNaCh IIA second repeat – NMR<br />
**[[1qg9]] – raNaCh IIA second repeat – NMR<br />
**[[5ayq]], [[5xax]], [[5xaw]] - mNaV 4 residues 30-160 <br />
**[[5ayq]], [[5xax]], [[5xaw]] - mNaV 4 residues 30-160 <br />
 +
**[[5xsy]] – eeNaV 1.4 + beta 1 – electric eel - Cryo EM <br />
**[[5x0m]] – coNaCh - cockroach <br />
**[[5x0m]] – coNaCh - cockroach <br />
**[[4bgn]] – NaCh – Caldalkalibacillus thermarum – Cryo EM<br />
**[[4bgn]] – NaCh – Caldalkalibacillus thermarum – Cryo EM<br />
Line 99: Line 107:
*Sodium channel complex
*Sodium channel complex
-
**[[7dtd]] - hNaV 1.1 + hNav b 4 – Cryo EM<br />
 
-
**[[6agf]] - hNaV 1 + hNav 1.4 – Cryo EM<br />
 
**[[6j8e]] - hNaV 2 + hNav 1.2 + Mu-conotoxin – Cryo EM<br />
**[[6j8e]] - hNaV 2 + hNav 1.2 + Mu-conotoxin – Cryo EM<br />
**[[6j8g]], [[6j8h]], [[6j8i]], [[6j8j]] - hNaV 2 + hNaV 1 + hNav 1.7 + toxin – Cryo EM<br />
**[[6j8g]], [[6j8h]], [[6j8i]], [[6j8j]] - hNaV 2 + hNaV 1 + hNav 1.7 + toxin – Cryo EM<br />
**[[6mba]], [[6mc9]] – hNaV 1.4 C terminal + calmodulin <br />
**[[6mba]], [[6mc9]] – hNaV 1.4 C terminal + calmodulin <br />
-
**[[6wth]] – hENaC ++g subunits + antibody – Cryo EM<br />
+
**[[6wth]] – hENaC alpha+beta+gamma subunits + antibody – Cryo EM<br />
-
**[[7w77]], [[7w7f]] – hNaV 1.3 beta1+beta2 + hNaV type 3 subunit alpha – Cryo EM<br />
+
**[[6lqa]] – hNaV 1.5 + quinidine - Cryo EM<br />
**[[6lqa]] – hNaV 1.5 + quinidine - Cryo EM<br />
**[[4ovn]], [[5dbr]], [[4djc]], [[6mud]] – hNaV 1.5 C terminal + calmodulin <br />
**[[4ovn]], [[5dbr]], [[4djc]], [[6mud]] – hNaV 1.5 C terminal + calmodulin <br />
**[[4dck]], [[4jq0]] – hNaV 1.5 C terminal + calmodulin + fibroblast growth factor <br />
**[[4dck]], [[4jq0]] – hNaV 1.5 C terminal + calmodulin + fibroblast growth factor <br />
**[[4jpz]] – hNaV 1.2 C terminal + calmodulin + fibroblast growth factor 13<br />
**[[4jpz]] – hNaV 1.2 C terminal + calmodulin + fibroblast growth factor 13<br />
-
**[[8gz1]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha – Cryo EM<br />
 
**[[8gz2]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha + toxin – Cryo EM<br />
**[[8gz2]] – hNaV 1.6 beta1+beta2 + hNaV type 8 subunit alpha + toxin – Cryo EM<br />
-
**[[7w9l]], [[7w9t]] – hNaV 1.7 (mutant) + beta-1 + beta-2 – Cryo EM<br />
 
-
**[[7w9k]] – hNaV 1.7 beta-1 + beta-2 – Cryo EM<br />
 
**[[7w9m]], [[7w9p]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + toxin – Cryo EM<br />
**[[7w9m]], [[7w9p]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + toxin – Cryo EM<br />
**[[7xm9]], [[7xmf]], [[7xmg]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + inhibitor – Cryo EM<br />
**[[7xm9]], [[7xmf]], [[7xmg]] – hNaV 1.7 beta1+beta2 + hNaV type 9 subunit alpha + inhibitor – Cryo EM<br />
**[[7we4]], [[7wel]], [[7wfr]] – hNaV 1.8 + inhibitor – Cryo EM<br />
**[[7we4]], [[7wel]], [[7wfr]] – hNaV 1.8 + inhibitor – Cryo EM<br />
-
**[[7tj9]] – hNaV type 7 alpha + beta-3 – Cryo EM<br />
 
**[[6mue]] – raNaV 1.4 + calmodulin <br />
**[[6mue]] – raNaV 1.4 + calmodulin <br />
**[[6uz0]] – raNaV 5 + flecainide - Cryo EM<br />
**[[6uz0]] – raNaV 5 + flecainide - Cryo EM<br />
**[[7k18]] – raNaV 5 + toxin - Cryo EM<br />
**[[7k18]] – raNaV 5 + toxin - Cryo EM<br />
-
**[[5xsy]] – eeNaV 1.4 + b 1 – electric eel - Cryo EM <br />
 
**[[6a90]], [[6a91]], [[6a95]] – coNaCh + toxin – Cryo EM <br />
**[[6a90]], [[6a91]], [[6a95]] – coNaCh + toxin – Cryo EM <br />
**[[7pg8]], [[7pgb]] – AeNaCh pore + antibody<br />
**[[7pg8]], [[7pgb]] – AeNaCh pore + antibody<br />
 +
*Sodium channel, pre-activated. NavAb
*Sodium channel, pre-activated. NavAb

Revision as of 09:32, 6 June 2023

3D structures of ion channels

Updated on 06-June-2023


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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