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7xxh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11== | |
| - | + | <StructureSection load='7xxh' size='340' side='right'caption='[[7xxh]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xxh]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XXH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AD:2-(METHYLSULFANYL)ADENOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>6AD</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xxh OCA], [https://pdbe.org/7xxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xxh RCSB], [https://www.ebi.ac.uk/pdbsum/7xxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xxh ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Han S]] | ||
| + | [[Category: Li B]] | ||
| + | [[Category: Tan Q]] | ||
| + | [[Category: Wu B]] | ||
| + | [[Category: Zhao Q]] | ||
Revision as of 05:34, 7 June 2023
Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11
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Categories: Homo sapiens | Large Structures | Han S | Li B | Tan Q | Wu B | Zhao Q
