7xxi

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m (Protected "7xxi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7xxi is ON HOLD
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==Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi==
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<StructureSection load='7xxi' size='340' side='right'caption='[[7xxi]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xxi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XXI FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AD:2-(METHYLSULFANYL)ADENOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>6AD</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xxi OCA], [https://pdbe.org/7xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xxi RCSB], [https://www.ebi.ac.uk/pdbsum/7xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xxi ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Han S]]
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[[Category: Li B]]
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[[Category: Tan Q]]
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[[Category: Wu B]]
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[[Category: Zhao Q]]

Revision as of 05:34, 7 June 2023

Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi

PDB ID 7xxi

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OCA

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