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8cxc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics== | |
| - | + | <StructureSection load='8cxc' size='340' side='right'caption='[[8cxc]], [[Resolution|resolution]] 4.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8cxc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CXC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxc OCA], [https://pdbe.org/8cxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxc RCSB], [https://www.ebi.ac.uk/pdbsum/8cxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxc ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Bandaranayake AD]] |
| - | [[Category: | + | [[Category: Carter J]] |
| - | [[Category: | + | [[Category: Chan MK]] |
| + | [[Category: Clarke M]] | ||
| + | [[Category: Correnti CE]] | ||
| + | [[Category: Friend DJ]] | ||
| + | [[Category: Lin I]] | ||
| + | [[Category: Mehlin C]] | ||
| + | [[Category: Meshinchi S]] | ||
| + | [[Category: Olson JM]] | ||
| + | [[Category: Pilat K]] | ||
| + | [[Category: Ruff RO]] | ||
| + | [[Category: Rupert PB]] | ||
| + | [[Category: Strong RK]] | ||
Revision as of 05:38, 7 June 2023
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
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Categories: Homo sapiens | Large Structures | Mus musculus | Bandaranayake AD | Carter J | Chan MK | Clarke M | Correnti CE | Friend DJ | Lin I | Mehlin C | Meshinchi S | Olson JM | Pilat K | Ruff RO | Rupert PB | Strong RK
