8i6h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the African swine fever virus DNA sliding clamp (selenomethionine form)== | |
| - | + | <StructureSection load='8i6h' size='340' side='right'caption='[[8i6h]], [[Resolution|resolution]] 2.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8i6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/African_swine_fever_virus_BA71V African swine fever virus BA71V]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I6H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i6h OCA], [https://pdbe.org/8i6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i6h RCSB], [https://www.ebi.ac.uk/pdbsum/8i6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i6h ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VF301_ASFB7 VF301_ASFB7] Plays a role in the inhibition of host innate immune system by acting as a negatively regulator of type I interferon production. Mechanistically, interacts with and prevents host IRF3 nuclear localization to inhibit its transcriptional activity.<ref>PMID:36099692</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: African swine fever virus BA71V]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gong P]] | ||
| + | [[Category: Wu J]] | ||
Revision as of 05:42, 7 June 2023
Crystal structure of the African swine fever virus DNA sliding clamp (selenomethionine form)
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