8srz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a bacterial death-like domain from Lysobacter enzymogenes== | |
| - | + | <StructureSection load='8srz' size='340' side='right'caption='[[8srz]], [[Resolution|resolution]] 1.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8srz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysobacter_enzymogenes Lysobacter enzymogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8srz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8srz OCA], [https://pdbe.org/8srz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8srz RCSB], [https://www.ebi.ac.uk/pdbsum/8srz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8srz ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Johnson | + | [https://www.uniprot.org/uniprot/PROT2_LYSEN PROT2_LYSEN] Possibly a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death. Involved in defense against bacteriophages. When this probable 4 gene operon (bGSDM-FE772_23060-FE772_23065-FE772_23070) is inserted into E.coli it provides nearly 100-fold protection against phages T5 and T6 and about 8-fold against phage T4. The operon without bGSDM no longer protects against phage.<ref>PMID:35025633</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lysobacter enzymogenes]] | ||
| + | [[Category: Johnson AG]] | ||
| + | [[Category: Kranzusch PJ]] | ||
Revision as of 05:44, 7 June 2023
Structure of a bacterial death-like domain from Lysobacter enzymogenes
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