5buh

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==Influenza PB2 bound to a hydroxymethyl azaindole inhibitor==
==Influenza PB2 bound to a hydroxymethyl azaindole inhibitor==
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<StructureSection load='5buh' size='340' side='right' caption='[[5buh]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='5buh' size='340' side='right'caption='[[5buh]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5buh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a0 I75a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5buh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Beijing/39/1975(H3N2)) Influenza A virus (A/Beijing/39/1975(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BUH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4V7:N-[(1R,3S)-3-({5-FLUORO-2-[5-FLUORO-2-(HYDROXYMETHYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]PYRIMIDIN-4-YL}AMINO)CYCLOHEXYL]PYRROLIDINE-1-CARBOXAMIDE'>4V7</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4V7:N-[(1R,3S)-3-({5-FLUORO-2-[5-FLUORO-2-(HYDROXYMETHYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]PYRIMIDIN-4-YL}AMINO)CYCLOHEXYL]PYRROLIDINE-1-CARBOXAMIDE'>4V7</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383596 I75A0])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5buh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5buh OCA], [https://pdbe.org/5buh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5buh RCSB], [https://www.ebi.ac.uk/pdbsum/5buh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5buh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5buh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5buh OCA], [http://pdbe.org/5buh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5buh RCSB], [http://www.ebi.ac.uk/pdbsum/5buh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5buh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PB2_I75A0 PB2_I75A0]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
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[https://www.uniprot.org/uniprot/PB2_I75A0 PB2_I75A0] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5buh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5buh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: I75a0]]
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[[Category: Large Structures]]
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[[Category: Jacobs, M D]]
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[[Category: Jacobs MD]]
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[[Category: Immune system]]
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[[Category: Influenza]]
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[[Category: Polymerase]]
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[[Category: Small molecule inhibitor]]
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Revision as of 06:08, 7 June 2023

Influenza PB2 bound to a hydroxymethyl azaindole inhibitor

PDB ID 5buh

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