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| | <StructureSection load='5bxj' size='340' side='right'caption='[[5bxj]], [[Resolution|resolution]] 1.24Å' scene=''> | | <StructureSection load='5bxj' size='340' side='right'caption='[[5bxj]], [[Resolution|resolution]] 1.24Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5bxj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5bxj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BXJ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NPO:P-NITROPHENOL'>NPO</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NPO:P-NITROPHENOL'>NPO</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP5, AIG6, FKBP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxj OCA], [https://pdbe.org/5bxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bxj RCSB], [https://www.ebi.ac.uk/pdbsum/5bxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bxj ProSAT]</span></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxj OCA], [http://pdbe.org/5bxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bxj RCSB], [http://www.ebi.ac.uk/pdbsum/5bxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bxj ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. | + | [https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[FK506 binding protein|FK506 binding protein]] | + | *[[FKBP 3D structures|FKBP 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Peptidylprolyl isomerase]]
| + | [[Category: Chen Z]] |
| - | [[Category: Chen, Z]] | + | [[Category: Han J]] |
| - | [[Category: Han, J]] | + | [[Category: He YX]] |
| - | [[Category: He, Y X]] | + | [[Category: Jia W]] |
| - | [[Category: Jia, W]] | + | [[Category: Li X]] |
| - | [[Category: Li, X]] | + | [[Category: Tao X]] |
| - | [[Category: Tao, X]] | + | [[Category: Wang Z]] |
| - | [[Category: Wang, Z]] | + | [[Category: Wu D]] |
| - | [[Category: Wu, D]] | + | |
| - | [[Category: 4-nitrophenol]]
| + | |
| - | [[Category: Cochaperone]]
| + | |
| - | [[Category: Fk506]]
| + | |
| - | [[Category: Isomerase]]
| + | |
| Structural highlights
Function
FKBP5_HUMAN Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
Publication Abstract from PubMed
The compound p-nitrophenol, which shows the anti-androgenic activity, can easily become anthropogenic pollutants and pose a threat to the environment and human health. Previous work indicates that the anti-androgenic mechanism of p-nitrophenol is complex and may involve several components in the AR signaling pathway, but the molecular details of how p-nitrophenol inhibits AR signaling are still not quite clear. Here, we characterized p-nitrophenol binds to the FK1 domain of an AR positive regulator FKBP51 with micromolar affinity and structural analysis of FK1 domain in complex with p-nitrophenol revealed that p-nitrophenol occupies a hydrophobic FK1 pocket that is vital for AR activity enhancement. Molecular dynamics simulation indicated that p-nitrophenol is stably bound to the FK1 pocket and the hotspot residues that involved p-nitrophenol binding are mainly hydrophobic and overlap with the AR interaction site. Furthermore, we showed that p-nitrophenol inhibits the androgen-dependent growth of human prostate cancer cells, possibly through down-regulating the expression levels of AR activated downstream genes. Taken together, our data suggests that p-nitrophenol suppresses the AR signaling pathway at least in part by blocking the interaction between AR and its positive regulator FKBP51. We believe that our findings could provide new guidelines for assessing the potential health effects of p-nitrophenol.
The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells.,Wu D, Tao X, Chen ZP, Han JT, Jia WJ, Zhu N, Li X, Wang Z, He YX J Hazard Mater. 2016 Apr 15;307:193-201. doi: 10.1016/j.jhazmat.2015.12.045. Epub, 2015 Dec 29. PMID:26780698[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Wu D, Tao X, Chen ZP, Han JT, Jia WJ, Zhu N, Li X, Wang Z, He YX. The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells. J Hazard Mater. 2016 Apr 15;307:193-201. doi: 10.1016/j.jhazmat.2015.12.045. Epub, 2015 Dec 29. PMID:26780698 doi:http://dx.doi.org/10.1016/j.jhazmat.2015.12.045
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