1l0q
From Proteopedia
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'''Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein''' | '''Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein''' | ||
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[[Category: Zhang, R G.]] | [[Category: Zhang, R G.]] | ||
[[Category: 7-bladed beta-propeller]] | [[Category: 7-bladed beta-propeller]] | ||
| - | [[Category: | + | [[Category: Pkd superfamily]] |
| - | [[Category: | + | [[Category: S-layer]] |
| - | [[Category: | + | [[Category: Slp]] |
| - | [[Category: | + | [[Category: Surface layer protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:24:41 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 20:24, 2 May 2008
Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein
Overview
The surface layer of archaeobacteria protects cells from extreme environments and, in Methanosarcina, may regulate cell adhesion. We identify three domain types that account for the complete architecture of numerous Methanosarcina surface layer proteins (SLPs). We solve the crystal structure for two of these domains, which correspond to the two N-terminal domains of an M. mazei SLP. One domain displays a unique, highly symmetrical, seven-bladed beta propeller fold, and the other belongs to the polycystic kidney disease (PKD) superfamily fold. The third domain is predicted to adopt a beta helix fold. These domains have homologs in metazoan cell surface proteins, suggesting remarkable relationships between domains in archaeal SLPs and metazoan cell surface proteins.
About this Structure
1L0Q is a Single protein structure of sequence from Archaea. Full crystallographic information is available from OCA.
Reference
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins., Jing H, Takagi J, Liu JH, Lindgren S, Zhang RG, Joachimiak A, Wang JH, Springer TA, Structure. 2002 Oct;10(10):1453-64. PMID:12377130 Page seeded by OCA on Fri May 2 23:24:41 2008
