5c37

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='5c37' size='340' side='right'caption='[[5c37]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5c37' size='340' side='right'caption='[[5c37]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5c37]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C37 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5c37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C37 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XN:6-{[(3R)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-5-[4-(1-METHYL-1H-INDAZOL-5-YL)PHENYL]-4,6-DIAZASPIRO[2.4]HEPT-4-EN-7-ONE'>4XN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4XN:6-{[(3R)-1-(CYCLOPROPYLCARBONYL)PYRROLIDIN-3-YL]METHYL}-5-[4-(1-METHYL-1H-INDAZOL-5-YL)PHENYL]-4,6-DIAZASPIRO[2.4]HEPT-4-EN-7-ONE'>4XN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FASN, FAS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c37 OCA], [https://pdbe.org/5c37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c37 RCSB], [https://www.ebi.ac.uk/pdbsum/5c37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c37 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c37 OCA], [http://pdbe.org/5c37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c37 RCSB], [http://www.ebi.ac.uk/pdbsum/5c37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c37 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
+
[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
==See Also==
==See Also==
Line 15: Line 14:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Grasberger, B]]
+
[[Category: Grasberger B]]
-
[[Category: Milligan, C M]]
+
[[Category: Milligan CM]]
-
[[Category: Schubert, C]]
+
[[Category: Schubert C]]
-
[[Category: Vo, K]]
+
[[Category: Vo K]]
-
[[Category: Beta-ketoacyl reductase]]
+
-
[[Category: Cancer]]
+
-
[[Category: Fatty acid synthase]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+

Revision as of 06:18, 7 June 2023

Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor

PDB ID 5c37

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools