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| | <StructureSection load='5c3l' size='340' side='right'caption='[[5c3l]], [[Resolution|resolution]] 2.90Å' scene=''> | | <StructureSection load='5c3l' size='340' side='right'caption='[[5c3l]], [[Resolution|resolution]] 2.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5c3l]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog] and [http://en.wikipedia.org/wiki/Arabian_camel Arabian camel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5c3l]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C3L FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3l OCA], [https://pdbe.org/5c3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c3l RCSB], [https://www.ebi.ac.uk/pdbsum/5c3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3l ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGC84997 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), nup62, IL4I1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), Immunoglobulin G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9838 Arabian camel])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3l OCA], [http://pdbe.org/5c3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3l RCSB], [http://www.ebi.ac.uk/pdbsum/5c3l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3l ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/K9ZTJ6_XENLA K9ZTJ6_XENLA] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: African clawed frog]] | + | [[Category: Camelus dromedarius]] |
| - | [[Category: Arabian camel]]
| + | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Chug, H]] | + | [[Category: Xenopus laevis]] |
| - | [[Category: Gorlich, D]] | + | [[Category: Chug H]] |
| - | [[Category: Hulsmann, B B]] | + | [[Category: Gorlich D]] |
| - | [[Category: Pleiner, T]] | + | [[Category: Hulsmann BB]] |
| - | [[Category: Trakhanov, S]] | + | [[Category: Pleiner T]] |
| - | [[Category: Heterotrimeric coiled coil]]
| + | [[Category: Trakhanov S]] |
| - | [[Category: Kink containing coiled-coil]]
| + | |
| - | [[Category: Nucleoporin]]
| + | |
| - | [[Category: Six helix-bundle]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| Structural highlights
Function
K9ZTJ6_XENLA
Publication Abstract from PubMed
Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport and gain transport selectivity through nucleoporin FG domains. Here, we report a structural analysis of the FG Nup62*58*54 complex, which is a crucial component of the transport system. It comprises a approximately 13 nm long trimerization interface with an unusual 2W3F coil, a canonical heterotrimeric coiled coil, and a kink that enforces a compact six-helix bundle. Nup54 also contains a ferredoxin-like domain. We further identified a heterotrimeric Nup93-binding module for NPC anchorage. The quaternary structure alternations in the Nup62 complex, which were previously proposed to trigger a general NPC-gating, are incompatible with the trimer structure. We suggest that the highly elongated Nup62 complex projects barrier-forming FG-repeats far into the central NPC channel, supporting a barrier that guards the entire cross-section.
Crystal structure of the metazoan Nup62*Nup58*Nup54 nucleoporin complex.,Chug H, Trakhanov S, Hulsmann BB, Pleiner T, Gorlich D Science. 2015 Aug 20. pii: aac7420. PMID:26292704[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Chug H, Trakhanov S, Hulsmann BB, Pleiner T, Gorlich D. Crystal structure of the metazoan Nup62*Nup58*Nup54 nucleoporin complex. Science. 2015 Aug 20. pii: aac7420. PMID:26292704 doi:http://dx.doi.org/10.1126/science.aac7420
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