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| | <StructureSection load='5c5x' size='340' side='right'caption='[[5c5x]], [[Resolution|resolution]] 2.60Å' scene=''> | | <StructureSection load='5c5x' size='340' side='right'caption='[[5c5x]], [[Resolution|resolution]] 2.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5c5x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C5X FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3d9s|3d9s]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [https://pdbe.org/5c5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [https://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AQP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5x OCA], [http://pdbe.org/5c5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c5x RCSB], [http://www.ebi.ac.uk/pdbsum/5c5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c5x ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN]] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. | + | [https://www.uniprot.org/uniprot/AQP5_HUMAN AQP5_HUMAN] Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Bill, R M]] | + | [[Category: Bill RM]] |
| - | [[Category: Conner, A C]] | + | [[Category: Conner AC]] |
| - | [[Category: Conner, M T]] | + | [[Category: Conner MT]] |
| - | [[Category: Hedfalk, K]] | + | [[Category: Hedfalk K]] |
| - | [[Category: Kitchen, P]] | + | [[Category: Kitchen P]] |
| - | [[Category: Oeberg, F]] | + | [[Category: Oeberg F]] |
| - | [[Category: Sjoehamn, J]] | + | [[Category: Sjoehamn J]] |
| - | [[Category: Toernroth-Horsefield, S]] | + | [[Category: Toernroth-Horsefield S]] |
| - | [[Category: Membrane protein]]
| + | |
| - | [[Category: Transport protein]]
| + | |
| Structural highlights
Function
AQP5_HUMAN Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions.
Publication Abstract from PubMed
Aquaporin membrane protein channels mediate cellular water flow. Human aquaporin 5 (AQP5) is highly expressed in the respiratory system and secretory glands where it facilitates the osmotically-driven generation of pulmonary secretions, saliva, sweat and tears. Dysfunctional trafficking of AQP5 has been implicated in several human disease states, including Sjogren's syndrome, bronchitis and cystic fibrosis. In order to investigate how the plasma membrane expression levels of AQP5 are regulated, we studied real-time translocation of GFP-tagged AQP5 in HEK293 cells. We show that AQP5 plasma membrane abundance in transfected HEK293 cells is rapidly and reversibly regulated by at least three independent mechanisms involving phosphorylation at Ser156, protein kinase A activity and extracellular tonicity. The crystal structure of a Ser156 phosphomimetic mutant indicates that its involvement in regulating AQP5 membrane abundance is not mediated by a conformational change of the carboxy-terminus. We suggest that together these pathways regulate cellular water flow.
Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways.,Kitchen P, Oberg F, Sjohamn J, Hedfalk K, Bill RM, Conner AC, Conner MT, Tornroth-Horsefield S PLoS One. 2015 Nov 16;10(11):e0143027. doi: 10.1371/journal.pone.0143027., eCollection 2015. PMID:26569106[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Kitchen P, Oberg F, Sjohamn J, Hedfalk K, Bill RM, Conner AC, Conner MT, Tornroth-Horsefield S. Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways. PLoS One. 2015 Nov 16;10(11):e0143027. doi: 10.1371/journal.pone.0143027., eCollection 2015. PMID:26569106 doi:http://dx.doi.org/10.1371/journal.pone.0143027
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