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5c6t
From Proteopedia
(Difference between revisions)
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==Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab== | ==Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab== | ||
| - | <StructureSection load='5c6t' size='340' side='right' caption='[[5c6t]], [[Resolution|resolution]] 3.60Å' scene=''> | + | <StructureSection load='5c6t' size='340' side='right'caption='[[5c6t]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5c6t]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5c6t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_Towne Human herpesvirus 5 strain Towne]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C6T FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c6t OCA], [https://pdbe.org/5c6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c6t RCSB], [https://www.ebi.ac.uk/pdbsum/5c6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c6t ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GB_HCMVT GB_HCMVT] Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Participates also in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity). Viral ligand for CD209/DC-SIGN. This interaction allows capture of viral particles by dendritic (DCs) cells and subsequent virus transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. CMV subverts the migration properties of dendritic cells to gain access to target organs or susceptible cells. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5c6t" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5c6t" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Glycoproteins B and D|Glycoproteins B and D]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Human]] | + | [[Category: Human herpesvirus 5 strain Towne]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Carfi A]] |
| - | [[Category: | + | [[Category: Chandramouli S]] |
| - | [[Category: | + | [[Category: Ciferri C]] |
| - | [[Category: | + | [[Category: Settembre EC]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 06:22, 7 June 2023
Crystal structure of HCMV glycoprotein B in complex with 1G2 Fab
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