This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ki0
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1ki0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ki0, resolution 1.75Å" /> '''The X-ray Structure...)
Next diff →
Revision as of 15:44, 12 November 2007
|
The X-ray Structure of Human Angiostatin
Contents |
Overview
Angiogenesis inhibitors have gained much public attention recently as, anti-cancer agents and several are currently in clinical trials, including, angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle, lysine-binding sites contain a bound bicine molecule of crystallization, while the former of kringle 2 and kringle 3 are cofacial. Moreover, the, separation of the kringle 2 and kringle 3 lysiner binding sites is, sufficient to accommodate the alpha-helix of the 30 residue peptide VEK-30, found in the kringle 2/VEK-30 complex. Together the three kringles produce, a central cavity suggestive of a unique domain where they may function in, concert.
Disease
Known diseases associated with this structure: Conjunctivitis, ligneous OMIM:[173350], Plasminogen Tochigi disease OMIM:[173350], Plasminogen deficiency, types I and II OMIM:[173350], Thrombophilia, dysplasminogenemic OMIM:[173350]
About this Structure
1KI0 is a Single protein structure of sequence from Homo sapiens with BCN as ligand. Active as Plasmin, with EC number 3.4.21.7 Full crystallographic information is available from OCA.
Reference
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin., Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH, J Mol Biol. 2002 May 10;318(4):1009-17. PMID:12054798
Page seeded by OCA on Mon Nov 12 17:51:10 2007
