User:Daniel Key Takemoto/Sandbox 1

Fragile X messenger ribonucleoprotein (FMRP) is encoded by the fragile X messenger ribonucleoprotein 1 (FMR1) gene, located in the X chromossome, associated with the fragile X syndrome, Fragile X Tremor/Ataxia Syndrome (FXTAS) and Premature Ovarian Failure (POF1). The FMRP binds to RNAs and its own FMR1 transcripts, possibly a self-regulatory mechanism. A motif that is going to be explored is the RGG motif, that the protein uses to bind to guanine G-quadruplexes a structure that consists of nucleic acid folding in which four guanines arrange in a planar conformation stabilized by Hoogsteen-trype hydrogen bonds, named tetrad.

RGG motif

Different domains and motifs mediate the RNA binding mechanism and the exon 15-encoded RGG (arginine - glycine - glycine) motif is one of them.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Disease

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Structural highlights

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