1kik
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(New page: 200px<br /> <applet load="1kik" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kik" /> '''SH3 Domain of Lymphocyte Specific Kinase (L...)
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Revision as of 15:44, 12 November 2007
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SH3 Domain of Lymphocyte Specific Kinase (LCK)
Contents |
Overview
BACKGROUND: Protein tyrosine kinases are involved in signal transduction, pathways that regulate cell growth, differentiation, activation and, transformation. Human lymphocyte specific kinase (Lck) is a 56 kDa protein, involved in T-cell- and IL2-receptor signaling. Three-dimensional, structures are known for SH3, SH2 and kinase domains of Lck as well as for, other tyrosine kinases. No structure is known for the unique domain of any, Src-type tyrosine kinase. RESULTS: Lck(1-120) comprising unique and SH3, domains was structurally investigated by nuclear magnetic resonance, spectroscopy. We found the unique domain, in contrast to the SH3 part, to, have basically no defined structural elements. The solution structure of, the SH3 part could be determined with very high precision. It does not, show significant differences to Lck SH3 in the absence of the unique, domain. Minor differences were observed to the X-ray structure of Lck SH3., CONCLUSION: The unique domain of Lck does not contain any defined, structure elements in the absence of ligands and membranes. Presence of, the unique domain is not relevant to the three-dimensional structure of, the Lck SH3 domain.
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
1KIK is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Structure determination of human Lck unique and SH3 domains by nuclear magnetic resonance spectroscopy., Briese L, Willbold D, BMC Struct Biol. 2003 May 7;3:3. Epub 2003 May 7. PMID:12734017
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